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To evaluate the efficacy and tolerability of the newly developed antiepileptic drugs gabapentin,lamotrigine,tiagabine,topiramate,vigabatrin and zonisamide in patients with refractory partial epilepsy.All six drugs were significantly better than placebo at reducing frequency of seizures. These results do not allow an evidence based choice between these drugs as we have no conclusive indication of differences in efficacy or tolerability. |
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